- Form/Dosage Sol. Inj. 5000 UA
- QTY in box 1
Each vial of SP Gonadotropin contains 5000iu of Chorionic gonadotropin.
Human chorionic gonadotropin is a hormone found only in the placenta of pregnant women. For women, it does not play a significant role, but for athletes there are several very important and interesting aspects. Can mimic LH (HL), secreted by the pituitary gland it is he who gives the signal for testosterone production. Sex hormones act through negative feedback, when present in amounts too large (such as steroids, androgens or estrogens) sends a signal to the brain to stop the secretion of HL. During steroid cycles that extend over long periods, if testosterone secretion own is too long suppressed, the testes begin to atrophy to lose the functionality. The administration of the luteinizing hormone-like, you can restore testicular function and their return to normal size. This is the main use of HCG.
Because mice produce testosterone accumulation in the body can have some anabolic properties but hardly significant. It is therefore not used by athletes for this purpose. But for someone who follows a cycle of steroids is almost essential. To keep gains during steroid cycle is imperative that their testosterone levels to normal. Without a natural endocrine response can’t keep a mass greater than the initial one.
The downside to HCG is that it suppresses testosterone production by luteinizing hormone replacement. HL is secreted by the pituitary galnda response to the hypothalamus to release another hormone, gonadotropin hormone. Given that an agent is introduced exogenously mimic HL, negative feedback hypothalamus sends a signal to stop production of the hormone gonadotropin, and implicitly that of HL. So HCG is always used with Clomed . When androgen levels in the body decreases, Clomed will lower estrogenic response steroidial inducing a deficit that will signal the hypothalamus to release gonadotropin hormone. It is important that HCG be used in combination with this drug, and his administration be discontinued at least 2 weeks prior to discontinue use of Clomed.
Also, prolonged use of HCG can desensitize the testicles to HL, which would mean back where you started. Side effects that may occur in some cases are acne and hair loss or prostate hypertrophy, but usually use 3-4 spatamani being too fast for these effects to manifest.
HCG is a fertility drug used and thus can cause high blood pressure.
Keep the material for injection in refrigerator.
HCG after cycles of steroid use long, 8 spatamani up. The normal duration of a cycle is between 8 and 12 weeks, but some opt for smaller cycles that impoune not necessarily use HCG after their completion.
More about the use of HCG can be found reading about post cycle therapy.
HCG is very important in post-cyclical recovery, but should not be given large doses and for a period of time too. And always must be accompanied by Clomed.
Human Chorionic Gonadotropin (HCG), a polypeptide hormone produced by the human placenta, is composed of an alpha and a beta sub-unit. The alpha sub-unit is essentially identical to the alpha sub-units of the human pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as to the alpha sub-unit of human thyroid-stimulating hormone (TSH). The beta sub-units of these hormones differ in amino acid sequence. Chorionic Gonadotropin is obtained from the human pregnancy urine. It is standardized by a biological assay procedure.
Chorionic Gonadotropin for Injection, SP-Laboratories is available in multiple dose glass vials containing 1,000 USP and 5,000 USP units.
The action of HCG is virtually identical to that of pituitary LH, although HCG appears to have a small degree of FSH activity as well. It stimulates production of gonadal steroid hormones by stimulating the interstitial cells (Leydig cells) of the testis to produce androgens and the corpus luteum of the ovary to produce progesterone.
Androgen stimulation in the male leads to the development of secondary sex characteristics and may stimulate testicular descent when no anatomical impediment to descent is present. This descent is usually reversible when HCG is discontinued. During the normal menstrual cycle, LH participates with FSH in the development and maturation of the normal ovarian follicle, and the mid-cycle LH surge triggers ovulation. HCG can substitute for LH in this function.
During a normal pregnancy, HCG secreted by the placenta maintains the corpus luteum after LH secretion decreases, supporting continued secretion of estrogen and progesterone and preventing menstruation. HCG has no known effect on fat mobilization, appetite or sense of hunger, or body fat distribution.
INDICATIONS AND USAGE:
HCG has not been demonstrated to be effective adjunctive therapy in the treatment of obesity. There is no substantial evidence that it increases weight loss beyond that resulting from caloric restriction, that it causes a more attractive or normal distribution of fat, or that it decreases the hunger and discomfort associated with calorie-restricted diets.
Prepubertal cryptorchidism not due to anatomical obstruction. In general, HCG is thought to induce testicular descent in situations when descent would have occurred at puberty. HCG thus may help predict whether or not orchiopexy will be needed in the future. Although, in some cases, descent following HCG administration is permanent, in most cases, the response is temporary. Therapy is usually instituted between the ages four and nine.
Selected cases of hypogonadotropic hypogonadism (hypogonadism secondary to a pituitary deficiency) in males.
Induction of ovulation and pregnancy in the anovulatory, infertile woman in whom the cause of anovulation is secondary and not due to primary ovarian failure, and who has been appropriately pretreated with human menotropins.
Precocious puberty, prostatic carcinoma or other androgen-dependent neoplasm, prior allergic reaction to HCG.
HCG should be used in conjunction with human menopausal gonadotropins only by physicians experienced with infertility problems who are familiar with the criteria for patient selection, contraindications, warnings, precautions and adverse reactions described in the package insert for menotropins. The principal serious adverse reactions are:
(1) Ovarian hyperstimulation, a syndrome of sudden ovarian enlargement, ascites with or without pain and/or pleural effusion,
(2) Rupture of ovarian cysts with resultant hemoperitoneum,
(3) Multiple births and
(4) Arterial thromboembolism.
Anaphylaxis and other hypersensitivity reactions have been reported with urinary-derived HCG products.
Induction of androgen secretion by HCG may induce precocious puberty in patients treated for cryptorchidism. Therapy should be discontinued if signs of precocious puberty occur.
Since androgens may cause fluid retention, HCG should be used with caution in patients with cardiac or renal disease, epilepsy, migraine or asthma.
Drug/Laboratory Test Interactions
Chorionic Gonadotropin may interfere with radioimmunoassay for gonadotropins, particularly luteinizing hormone.
Carcinogenesis, Mutagenesis, Impairment of Fertility
Long-term studies in animals have not been performed to evaluate the carcinogenic or mutagenic potential of Chorionic Gonadotropin.
Safety and effectiveness of Chorionic Gonadotropin in children below the age of four have not been established.
Teratogenic Effects: Pregnancy Category C– Chorionic Gonadotropin may cause fetal harm when administered to a pregnant woman. Defects of forelimbs and central nervous system and alterations in sex ratio have been reported in mice receiving combined gonadotropin and Chorionic Gonadotropin therapy in dosages to induce superovulation. Multiple ovulations with resulting plural gestations (mostly twins) have been reported to occur in approximately 20% of pregnancies when conception has followed Chorionic Gonadotropin therapy.
It is not known whether Chorionic Gonadotropin is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Chorionic Gonadotropin is administered to a nursing woman.
Headache, irritability, restlessness, depression, fatigue, edema, precocious puberty, gynecomastia and pain at the site of injection.
DOSAGE AND ADMINISTRATION:
Intramuscular Use Only
The dosage regimen employed in any particular case will depend upon the indication for use, the age and weight of the patient and the physician’s preference. The following regimens have been advocated by various authorities.
Selected Cases Of Hypogonadotropic Hypogonadism In Males
500 to 1,000 USP units three times a week for three weeks, followed by the same dose twice a week for three weeks.
4,000 USP units three times weekly for six to nine months, following which the dosage may be reduced to 2,000 USP units three times weekly for an additional three months.
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